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IFN- is produced mainly by nature killing (NK) cells and increases CD31 and vascular cell adhesion molecule (VCAM)-1, resulting in the expansion of innate immune cell infiltration (82)

WB and IHC analyses confirmed that RPTS downregulated SLC7A11 and GPX4 expression in excised tumors ( Figures 2H, I )

Better use of kidney cell-specific animal models with genetic manipulation of ceramide accumulation and degradation will be useful to identify which cell types are most affected by the action of ceramide

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This would suggest that the therapy with anti-classical IC (CTLA4 and PD1) is not appropriate as there is no possibility to relive the brake of the immune system