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Corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) secreted by the hypothalamus act on the anterior pituitary and accelerate the release of adrenocorticotropic hormone (ACTH) and its stimulation of the adrenal cortex, further triggering the secretion of cortisol and other hormones and ultimately reaching the target site through blood circulation, affecting the functional and immune states of the intestinal tract (111)

Mycobacterium tuberculosis (Mtb), for instance, secretes protein tyrosine phosphatase A, which inhibits GPX4 expression, thereby inducing ferroptosis and enhancing Mtb pathogenicity and transmission (66)

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(2006) Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model