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Researchers have also observed that glutathione regulates protein function through reversible S-glutathionylation of cysteine residues, modulating the activity of signaling proteins, transcription factors, and metabolic enzymes in response to oxidative conditions

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In addition, chronic hyperglycemia enhances mTOR and inhibits AMPK which is associated with decreased PDH activity and may underlie reduced oxidative metabolism during T2D-related diabetogenic metabolic stress (Haythorne et al., 2022)