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The presence of platelets in the spleen due to cancer or severe liver diseases, leukemia, certain types of anemia, viral infections, exposure to toxic chemicals, chemotherapy drugs, excessive alcohol consumption, lack of essential vitamins, autoimmune diseases, drug reactions, bacterial infections in the blood, pregnancy can cause low blood platelets

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Nausea is the most frequently reported adverse effect, potentially affecting thirty to forty percent of patients at some point during treatment, though the intensity typically diminishes over time as tolerance develops