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The role of the CEP as a nutritional and mechanical barrier may further support homeostasis amid fluctuating nutrient availability [14, 25, 58]

Strengths and limitations The main strengths of this study include the population-based cohort design, the large sample size of over 12 million live births, the detailed examination of the associations between the timing and intensity of maternal cigarette smoking and many congenital anomalies subtypes considered (including rare subtypes), the adjustment for several (but not all possible) covariates, and the sensitivity analyses used to confirm our findings

The daughter of legendary 1960s manager Don Arden (best known for dangling people out of hotel room windows), she managed and then married Ozzy

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