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Due to defective renal absorption (free) carnitine is excreted in the urine of patients with primary deficiency and can result in tissue carnitine levels dropping to below 10% of normal [14, 22, 2426]

Aside from reduced splanchnic perfusion leading to mucosal ischemia and enterocyte damage, factors contributing to the exercise-induced gastrointestinal syndrome might be thermal stress, oxidative stress, effects of gut microbiota, and inflammation [63,64,65]

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Why EPA and DHA Matter Most Research consistently shows that EPA and DHA provide the most significant health benefits