CrossRef Combined immune checkpoint inhibitorinduced type 1 diabetes: a rare but serious endocrinopathy Kasra Emami, Sonia Goyal, Vishal Akula, Peggy Amoakohene JCEM Case Reports.2026;[Epub] CrossRef Association of PD-1 gene polymorphisms and serum soluble PD-1 levels with type 1 diabetes mellitus susceptibility in a Chinese Han cohort: a case-control study Renhao Zhao, Xiuli Feng, Na Wang, Zijing Wang, Jing Liu, Guofeng Wang Frontiers in Immunology.2026;[Epub] CrossRef Immune checkpoint inhibitor-associated diabetic ketoacidosis induced by cadonilimab: a case report and literature review Yuchen Jiang, Yu Cui, Dan Su, Hao Yang, Xi Chen, Xiaodan Qian, Lidan Tang, Shan Xu Frontiers in Endocrinology.2026;[Epub] CrossRef Immune checkpoint inhibitor-associated diabetes mellitus: an overlooked immune-related adverse eventtwo case reports and a literature review Mengjia He, Zhenru Zheng, Xiaofan Guo, Gang Cheng, Shuang Zhang, Jinlong Liu, Jing Zhao Frontiers in Immunology.2026;[Epub] CrossRef Letter to the Editor: Akkermansia muciniphila serves as an immunomodulator for type 1 diabetes mellitus: Promises and pitfalls Ying Qian, Jun Xu, Jun-Min Wang, Xing-Li Wu, Yi-Yuan Zheng World Journal of Diabetes.2026;[Epub] CrossRef Association between HLA-DRB1*04:05 and the efficacy of immune checkpoint inhibitors for patients with advanced cancer Mayu Watanabe, Jun Eguchi, Atsushi Takamoto, Jun Wada Frontiers in Endocrinology.2026;[Epub] CrossRef PD-1/PD-L1 pathway and the U-Curve paradigm: implications for type 1 diabetes immunotherapy Jiahui Chen, Hanbin Zhang, Peng Yu, Linghua Fu, Pingping Yang European Journal of Medical Research.2026;[Epub] CrossRef PPAR activation sensitizes MSS gastrointestinal cancer cells to PD1 blockage Juliane Reichling, Beifang Li, Yanxiong Yu, Tobias Gutting, Philip Weidner, Carsten Sticht, Matthias P
It works best as an adjunct combined with in-clinic treatments rather than on its own
DOI: 10.3389/fmed.2022.964101 61
Moreover, peroxidation of molecules in the mitochondrial membranes alters the distribution of electrical charges across the membrane, which results in reduced levels of ATP in the cell and promotes another type of cell death called necrosis
In Phase 2, the most common side effects were mild to moderate gastrointestinal symptomsnausea, diarrhea, and vomitingthat typically diminished after the first few weeks
