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Wang DQ-H, Schmitz F, Kopin AS, Carey MC

In medullary thyroid carcinoma models, decitabine plus the mTOR inhibitor everolimus demonstrated strong synergistic antiproliferation (synergy index CI = 0.1) and apoptosis (90% increase in late apoptotic/necrotic cells), mediated by activation of the NGFR-MAPK10-TP53-Bax/Bcl-2 pathway [99]

In OCTN2, R459 (TM11) and E220 (TM4) form a salt bridge in the occluded conformation, that is broken in the inward-facing conformation

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