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In some embodiments, the invention encompasses contacting one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy

AOD-9604 in Obesity Problems and Fat Burning AOD-9604 as a lipolytic fragment of HGH was developed and thereafter studied most of all for its effective fat burning functions and as a potential anti-obesity drug