Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg 333 SMILES O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)NCC#C Purity (HPLC)

333 SMILES O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)NCC#C Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

411 SMILES OCCCCCCC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

823 Purity (HPLC) >= 95% Solubility DMSO

SiR-NHS is the NHS ester of SiR-6-COOH (652Ex/674Em) and can be conjugated to amine-containing molecules easily

333 SMILES BrCCCCCCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg 333 SMILES O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)NCC#C Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly