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doi: 10.1096/fj.201900217R [DOI] [PMC free article] [PubMed] [Google Scholar] 115.Thompson LE, Tuey SM, Gonzalez PG, et al

Cancer Cell 39 , 509528.e520 (2021)

In addition to clinical trials, some TCMs, such as Rhodiola rosea , 393 Hippophae rhamnoides , 394 Aesculus chinensis , 395 Portulaca oleracea Linn ( Portulacaceae ), 396 Phlomis younghusbandii Mukerj ( Lamiaceae ), 397 Pueraria lobata , 398 Eleutheroside B , 399 and Notoginsenoside R1 , 400,401 showed promise in preventing HAPE/HACE in rat models by inhibiting the infiltration of inflammatory cells, the production of inflammatory cytokines, and apoptosis/pyroptosis

Due to the high binding affinity of GHK tripeptides to copper ions, we used zebrafish as an in vivo model to elucidate whether recombinant GHK tripeptides possess detoxification potential against the cardiotoxicity raised by waterborne Cu(II) exposure