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Metabolism of acetaminophen (paracetamol) in plantstwo independent pathways result in the formation of a glutathione and a glucose conjugate Environmental Science and Pollution Research Springer Nature Link A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Are some people at increased risk of paracetamol induced liver injury? A critical review of the literature European Journal of Clinical Pharmacology Springer Nature Link glutathione depletion paracetamol overdose Full article: (acetaminophen) and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Liver injury induced by paracetamol File:Paracetamol metabolism it.svg Wikimedia Commons

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