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Although the precise prevalence of painful peripheral neuropathy in cirrhosis remains elusive, research has revealed that 15% of cirrhotic patients manifest neuropathic symptoms such as numbness and paraesthesia ( 10.3 Treatment and adjunctive management General principles include addressing comorbid symptoms (such as sleep, mood, memory, fatigue, and psychiatric disorders), emphasizing self-management tools, and employing multimodal therapies that combine several non-pharmacologic strategies

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Furthermore, melatonin-induced changes in glycosaminoglycan production may impact the TM, which regulates IOP, potentially influencing the pathophysiology of POAG (81)

These findings suggest that the combination of small molecule NNMT inhibitors with other nutritional supplements, such as the precursors of NAD + , may have the potential to enhance the efficacy of treatment for MetS and minimize the side effects caused by high pharmacological dosages (Roberti et al., 2021)