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* Correspondence: Yuyan Lan, [email protected] These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

TMAO and cardiovascular disease The connection between TMAO and CVD was first made using an animal model in 2011, which revealed that choline, TMAO and betaine were predictors of CVD risk

5.3 Chemical structure modification Chemical structure modification, including synthesizing analogs and designing prodrugs, is another effective approach

doi:10.1056/NEJMra2207599

Dividends and stability sometimes come as a package