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The rhythmic control of pyruvate dehydrogenase activity by brain and muscle ARNT-like 1 (BMAL1) indicates that a CCR2 antagonist administered at dawn may reduce neuroinflammation, while the same drug given at dusk could worsen it

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2C demonstrates the increased cytotoxic effect on MCF-7 cells with increased exposure time, without any significant effect on L-02 cells

The authors are grateful for the computing time granted by the LANCAD and CONAHCYT in the Supercomputer Hybrid Cluster Xiuhcoatl at General Coordination of Information and Communications Technologies (CGSTIC) of CINVESTAV Mxico