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Moreover, proinflammatory cytokines could activate the kynurenine pathway, leading to the increase of neurotoxic metabolites, including 3-hydroxykynurenine, 3-hydroxy-anthranilic acid, and quinolinic acid, to cause brain damage (Kim and Won, 2017)

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Deletions of genes and chromosomal regions was performed using SpEdit CRISPR-Cas9 methodology (Torres-Garcia et al, 2020a) or a selectable marker-based method (Bhler et al, 1998), using oligonucleotides listed in Table EV3

28 , 11361143 e1134 (2019)