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In SOD1 G93A mice, CuII (atsm) improves survival by 26% (Hilton et al., 2017) and was therefore more effective than riluzole (3% survival improvement) in this model (Mcallum et al., 2013

Additionally, such interventions may increase susceptibility to opportunistic infections and exacerbate systemic immune dysregulation in susceptible individuals (134)

& Greenplate, A

La Habana, 1983:195-237

We theorize that this displacement, in addition to the other LCS3-GSR interactions noted earlier, confer the ability of LCS3 to inhibit enzymatic activity