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ENTs treat a wide range of issues, ranging from acute to chronic

Yet, 6 months of transdermal nicotine administration (16 mg/day) to MCI patients improves primary and secondary cognitive measures of attention, memory, and mental processing (Heffernan and O'Neill, 2013)

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The rewarding and cognitive effects of nicotine are mediated through the activation of mesocortical DA receptors in the prefrontal cortex and anterior cingulate cortex, while the activation of DA receptors by nicotine in the nucleus accumbens and amygdala modulate synaptic plasticity and long-term potentiation that are more important in addiction