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This practice was abandoned once CFC propellants were no longer used and dosage counters became available

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All patients with asthma met one of the following criteria: FEV 1 changed over 12% and 200 mL after bronchodilator response, and/or there was significant airway hyperresponsiveness to methacholine or mannitol provocation (Table 1)

They have been marketed as an appealing alternative to spit tobacco because there is no need to spit (like with chewing tobacco), and the pouches do not produce odor, smoke or vapor

UK Parliament records confirm there is no legal nicotine limit for pouches, with products on the market ranging from 2 mg up to 150 mg per pouch