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but it has the disadvantage of dispersing part of the aroma, and is therefore generally resorted to only when time presses

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Seminar www.thelancet.com Vol 371 June 14, 2008 2029 its receptors on neurons containing -aminobutyric acid (GABA), which mediate inhibition, and on glutamate- containing cells has been implicated in extending the e ects of drug on synaptic function.28 Nicotine administration also increases the extracellular nor- adrenaline in speci c parts of the brain;2932 however, the e ects of nicotine on neurotransmitters such as serotonin or other CNS neurotransmitter systems such as the endocannabinoids and neuropeptides have been less studied