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Abstract Parkinsons disease (PD) is a progressive neurodegenerative disorder traditionally characterized by dopaminergic neuronal loss in the substantia nigra and the accumulation of misfolded -synuclein (-syn) aggregates

4,42,43 The p300/CBP complex plays a central role in modifying histones, transcription factors (TFs), and other nuclear substrates

HP 13 C MR via dissolution dynamic nuclear polarization (dDNP) is an emerging imaging technology that allows direct visualization of metabolic conversion of 13 C-enriched molecules, and has been applied extensively to study metabolism in cells, tissues, animal models, and patients 22,23,24

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