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burgdorferi DbpA affect tissue tropism and disease manifestation of different LD genospecies [213]

Furthermore, enhanced glutamine metabolism has been shown to significantly increase -KG production, which, in turn, activates the mTOR1 signaling pathway and further inhibits the autophagy-promoting kinase (APCK) of the ULK1 complex by mediating site-specific phosphorylation of ULK1 (Ser637 and Ser757) and Atg13 (Ser258) activity, thereby promoting cancer cell proliferation [27]

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The samples were incubated at 37 C for 3 min, after which 0.5 ml of 4% (w/v) ammonium molybdate dissolved in 0.125 M H 2 SO 4 and 0.450 mL of 0.25 M H 2 SO 4 were added

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