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Airway epithelial barrier dysfunction not only impairs the physical barrier activity of airway epithelium, but further exposes sub-epithelial layers to exogenous substances, leading to a series of pathological processes such as airway inflammation, airway remodeling, airway hyperresponsiveness and increasing the rate of COPD exacerbation [7, 8]

FDA estimates that the proposed rule would result in a 15.1% decrease in smoking within 40 years, saving up to 654,000 lives

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