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Furthermore, it has been shown that p53 deficiency can be increased by NO-mediated oxidative stress (44)

Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells

Finally, it will be interesting to see how post-translational modifications such as lysine succinylation, which occurs at specific sites on GAC and has been suggested to both promote enzyme activation by stimulating oligomer (tetramer) formation [22] and to enhance ubiquitination and degradation [40], affects filament formation

It is not used to prevent malaria or to treat severe malaria (where it has affected the brain, lungs, or kidneys)