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All patients attempting to quit using tobacco should be encouraged to use effective pharmacotherapies (Table 3) for smoking cessation, 43 except when medically contraindicated or in specific populations in which there is insufficient evidence of effectiveness (e.g., pregnant women, smokeless tobacco users, light smokers, adolescents)

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Chemical Composition: What You're Actually Inhaling When comparing 1 cigarette vs 1 joint, the chemical profiles reveal significant differences: Cigarettes contain over 7,000 chemicals, including at least 70 known carcinogens Joints contain cannabinoids, terpenes, and fewer additives, but still produce tar and carbon monoxide when combusted Tobacco smoke contains nicotine, which is highly addictive Cannabis smoke contains THC, which has different addiction potential and mechanisms These chemical differences translate to varying health outcomes