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Mechanisms of development of chronic obstructive pulmonary disease-associated pulmonary hypertension

PubMed PMID:22397504 Matt GE, Quintana PJ, Zakarian JM, Fortmann AL, Chatfield DA, Hoh E, Uribe AM, Hovell MF

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Specifically, nicotine binds to the 7 receptors along glutamatergic neurons, stimulating their activity and enhancing NMDAR function, which together enhances dopaminergic neuronal activity (94)