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They either interact directly with the significant participants of the signalling cascade or may affect the signalling process indirectly by regulating the levels of ROS and phytohormones like Jasmonic acid, which thereby later control the plant responses to growth and development as well as stress tolerance [161]

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doi: 10.1371/journal.pone.0084034

The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model