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Goffman E

3.2.3 Immunological effects Evidence suggests that e-cigarettes compromise immune function ( In murine models, exposure to e-cigarette vapor significantly impaired pulmonary antimicrobial defenses ( Streptococcus pneumoniae compared with air-exposed controls

[ii] 2020 WHO tobacco fact sheet states "All forms of tobacco are harmful, and there is no safe level of exposure to tobaccosmokeless tobacco use is highly addictive and damaging to health. [iii] According to the CDC

6,7 Chronic obstructive pulmonary disease (COPD) hospitalization risk is higher among people living in regions of Appalachia, the southern Great Lakes, the Mississippi Delta, the Deep South, and West Texas

But this doesnt necessarily suggest a relationship between nicotine withdrawal and testosterone