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This model suggests that, beyond TG accumulation and inflammation, additional interrelated mechanisms such as lipotoxicity, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and inflammasome activation collectively contribute to the development and progression of MASLD

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They first introduced a sulfonamide instead of the unstable ester and introduced a benzyl ring 2 on the NH to obtain the sulfonamide analogue compound 38 (UAMC-2418)