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Mediators of endothelial cell activation are diverse and include proinflammatory cytokines (tumor necrosis factor (TNF ), interleukin-1 (IL-1 )), bacterial (lipopolysaccharide) and endogenous toxins (oxLDL), vasoconstrictors (angiotensin II, endothelin-1), mechanical forces (shear stress, stretch), and extracellular matrix proteins (fibronectin, fibrinogen) [13, 5254]

Tian, H., Lin, S., Wu, J., Ma, M., Yu, J., Zeng, Y., Liu, Q., Chen, L., & Xu, J

Efficacy of l-ornithine l-aspartate in acute liver failure: a double-blind, randomized, placebo-controlled study

In this population, non-Hodgkin lymphoma occurred at a 1.94-fold increased incidence rate, and incidence of small intestinal cancer was increased 4.29-fold, compared with rates expected in the general population

PVN, Paraventricular nucleus