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Structural validation of metabolites with chemical standards Previously unknown metabolites discovered in this study were validated using chemical standards

Moreover, as microorganisms consume O 2 during their growth, chronic wounds become increasingly hypoxic, limiting cellular energy production and impairing the activity of essential growth factors required for tissue regeneration [56]

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The gut microbiota, however, serves as the master regulator of this metabolic network, where microbial BCAAs biosynthesis and catabolism dynamically control systemic BCAAs availability