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As PDH catalyzes a crucial reaction before acetyl-coA enters the TCA cycle, its repression is leading to the decreased levels of acetyl-coA and the accumulation of pyruvate ( miR-147b initiates a reversible state of tolerance to osimertinib in lung cancer cells by binding SDHD (Zhang et al., 2019)

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Because glutamine is the source of -KG, glutaminase inhibitors such as BPTES interfere with -KG homeostasis and lead to inhibited proliferation in cancer cells carrying this mutant IDH1 (Seltzer et al., 2010)

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