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Additional information Peer review information: Nature Communications thanks Paul Baird and the other anonymous reviewer(s) for their contribution to the peer review of this work

Taken together, these findings indicated that hepsin / mice experience heightened oxidative stress in the early stages of APAP exposure, suggesting that endogenous hepsin might protect against toxicity during the early stages of APAP exposure, thereby significantly influencing survival outcomes in drug-induced toxicity cases

The tone-up effect may vary depending on skin tone and the amount of product used

Recent trials investigating ES (O'Day et al., 2013) and DSF (Kelley et al., 2021) have demonstrated excellent safety profiles