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Ferroptosis, a recently characterized mode of cellular death, is intricately interwoven with diverse cellular metabolic pathways encompassing redox homeostasis and iron metabolism (36)

According to a recent study, melatonin targets mitochondria, scavenges free radicals and reduces oxidative damage, with a potential and promising therapeutic role in limiting muscle degeneration (mainly mitochondrial function) and sarcopenia (184)

10.1016/j.jmb.2022.167859 128 PrasadA.BaoB.BeckF.SarkarF

These pharmacological agents attenuate glucose reabsorption in the renal tubules through competitive inhibition of SGLT-2 proteins

Beyond their primary glycemic benefits, SGLT-2 inhibitors also exert positive effects on multiple parameters, including improvements in blood lipids (6) and blood pressure (7), as well as reductions in uric acid levels (8)