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Its worth noting that adverse effects are not common with high supplemental vitamin B12 intake, however, there is also no strong evidence to show that it has benefits in people who are not already deficient (largely due to the fact that your body only stores as much B12 as it needs and any excess will be excreted through your urine)

J Biol Chem 287:65396550

10.1002/lt.21482 67 TavanaiE.MohammadkhaniG

MHR Basic Sci Reprod Med 20(10):948959 Los M, Craen MVd, Penning LC, Schenk H, Westendorp M, Baeuerle PA, Drge W, Krammer PH, Fiers W, Schulze-Osthoff K (1995) Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis