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In insulin resistance or hyperinsulinemia, the heart experiences notable metabolic dysregulation, characterized by diminished glucose uptake and use alongside heightened dependence on fatty acid oxidation

In kidney biopsy samples from patients with DKD, xCT and Gpx4 mRNA expression was also reduced compared to that in control samples (26)

It is produced from the precursor thyroglobulin (this is not the same as thyroxine-binding globulin [TBG]), which is cleaved by enzymes to produce active T 4