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Mechanisms of Disease: metabolic effects of growth hormone and insulin-like growth factor 1

The presence of a catechol group in the B-ring, due to its ability to donate hydrogen, increases the formation of a relatively stable flavonoid-derived radical, which is the most important determinant of reactive oxygen and nitrogen species (RONS) inhibition (188)

Yoshitani M, Fukuda S, Itoi S, et al

But for those who need it, the 8 to 12 mg daily range corresponds to injectable doses of approximately 10 to 15 mg weekly when adjusted for sublingual bioavailability