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Neuropsychiatr Dis Treat 24(14):367374

Cotter TG, Rinella M

Similar content being viewed by others Introduction Allergic rhinitis (AR) is a chronic, non-infectious nasal mucosal disease with recurrent nasal congestion, rhinorrhea, itching, and paroxysmal sneezing [1]

Protein purification under denaturing conditions: Proteins that are expressed as an inclusion body and have been solubilized with chaotrophic agents such as guanidine-HCl or urea can be purified by modifying the protocol to include the appropriate amount of denaturant (up to 6M guanidine-HCl or up to 8M urea) in the binding, wash and elution buffers

Present therapeutic approaches are predominantly symptomatic in nature and fail to halt the process of neurodegeneration, thereby underscoring an urgent imperative for disease-modifying strategies that target protein aggregation, oxidative stress, and neuroinflammatory processes