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Meta-analyses and observational studies also demonstrate that: Lower B12 levels are associated with peripheral neuropathy Elevated homocysteine and methylmalonic acid correlate with nerve dysfunction Supplementation is associated with reductions in neuropathic pain scores, particularly where deficiency exists While evidence specific to Mortons neuroma is limited, optimising vitamin B12 status is a low-risk and biologically sound consideration in patients with nerve-related foot pain

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J Exp Med 138 : 574592