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Alice de Boyer des Roches (UMR Herbivores, INRAE) and Dr

Ostojic, S

Numerous in vitro studies show that ITCs induce apoptosis via both intrinsic and extrinsic pathways (108)for instance, through caspase activation (109), mitochondrial dysfunction (110), and oxidative stress generation (111)

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Consequently, future research should focus on identifying precise therapeutic targets and characterizing the alterations in downstream signaling pathways, enabling berberine to exert a pivotal role in the treatment of DN by targeting these pathways