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Abstract Glycine is a fundamental neuroactive amino acid that serves dual roles in the central nervous system: acting as a primary inhibitory neurotransmitter via strychnine-sensitive glycine receptors and as an essential co-agonist at the N-methyl-D-aspartate (NMDA) receptor

85 In parallel, tumor necrosis factor alpha (TNF) stimulates ROS production and inhibits glutathione synthesis, thus sensitizing tumors to ferroptosis

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Systemically, Mlkl Adi-KO mice also exhibited reduced hepatic steatosis and triglyceride accumulation, reinforcing the importance of adipose-liver crosstalk in metabolic regulation

Normal tissues and derived cells were 96.2% genetically similar, while tumor tissues and derived cells were 97.7% genetically similar