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Enzymatic Mechanisms of Transsulfuration in Biology and Clinical Practice

Bouwes Bavinck JN, Vermeer BJ, Gevers Leuven JA, Koopman BJ, Wolthers BG

Cheesman, M

While the mechanism was not investigated in this clinical study, prior preclinical studies have identified -caryophyllene, a major constituent of Piper nigrum , as a selective cannabinoid receptor 2 (CB2) agonist, suggesting that endocannabinoid modulation may contribute to analgesic effects [149]