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At first, iPSC are driven towards a phenotype that is equivalent to the progenitor status, defined using appropriate combinations of markers for forebrain/midbrain, i.e., OTX2, FOXA2, and LMX1A expression

In addition, magnesium is involved in the regulation of various nerve receptors, such as NMDA and 5-HT3, which are involved in the development of neuropathic pain experienced by FM patients