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Cystine uptake assay For in vivo detection of tumor cell cystine uptake, 13 C 6 - 15 N 2 -labeled cystine was administered to mice via intraperitoneal (i.p.) injection

5) Irisflorentin blocks erastin/RSL3-induced ferroptosis and TGF-1-stimulated fibrosis in primary tubular cells and suppresses Smad3 phosphorylation/Nox4 to reduce UUO-induced injury and fibrosis (202)

[DOI] [Google Scholar] Chen J., Zhang L., Yang F., Yi J., Yang Z., Li Z., et al

In tumor cells, MYC-driven glutamine metabolism promotes tumor growth, drug resistance and immune escape [48], whereas MYC-regulated glutamine metabolism in immune cells supports the activation, proliferation and cytokine secretion of effector T cells and NK cells and enhances the immune response and other immune functions [49]

This in turn causes redness, inflammation, and general skin tightness