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Proximity labeling constitutes a powerful alternative to detect transient, less stable protein interactions in living cells, as this approach can identify proteins that are briefly close to the bait protein

doi: 10.1016/j.redox.2015.08.020 51 GutierrezD

General Vitamin B12 deficiency that is allowed to progress for longer than 3 months may produce permanent degenerative lesions of the spinal cord

For example, the motor protein kinesin requires the binding of active JNK to regulate microtubule dynamics and +TIP CLIP-170 rescuing activity (Daire et al., 2009