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Studies have shown that early treatment with resveratrol can significantly reduce hearing thresholds at all frequencies, and can reduce the mRNA expression levels of pro-apoptotic genes Bax and Bak, and increase the mRNA expression level of anti-apoptotic genes Bcl-2 and Bcl-xL, but there was no significant difference in hearing levels between the late treatment group and the control group [114]

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Therefore, once substances enter the CSF, they can easily diffuse across the ependymal layer and into the brain