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Furthermore, transcript levels for complex IV subunit COX-3 (CTC-3) were 6 times higher in WT during HS, which was comparable to the level measured in ctl-2(ua90)II strain both at OGT and HS (Figs 6H and S3)

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The result demonstrated restoration of enzyme activity in different organs of the CNS and peripheral nervous system as well as in typical accumulation zones after intraperitoneal injection of GALC CLEA NPs in Twitcher mice, which showed a return of enzyme activity in the brain to the level seen in unaffected mice (Figure 11B-G)