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As research continues to evolve, therapies targeting cellular metabolism may become increasingly important tools in preventive health and longevity strategies.

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T cells in coeliac disease: a rational target for diagnosis and therapy

Calorie restriction (1) reduces adipokine release which attenuates systemic inflammatory signaling (401), (2) reduces serum lipids and comorbidities associated with disease exacerbation (e.g., hypertension) (400), (3) activates autophagy, which protects against hepatic steatosis and inflammation (402), and (4) activates various molecular pathways (e.g., AMPK) which are associated with protection against NASH and atherosclerosis (403, 404)