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Therefore, in various stages of neurodegenerative disorders involving Parkinsons disease (PD) and AD, dysregulation of BDNF signaling is delayed until the development of advanced neurodegeneration (Faria et al., 2014a, 2014b)

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Subsequent work showed that GDH1 modulates NCR signaling via GATA transcription factors such as Gln3 and Gat1 , influencing their nuclear localization and downstream gene expression [14]