fsp1 is a glutathione-independent ferroptosis suppressor. suppressor protein 1 regulated oligodendrocytes ferroptosis rescued by idebenone in spinal cord injury GPX4-independent ferroptosis defense pathways. Cells

doi: 10.1038/35038557

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As GPX4 is entirely dependent on GSH to neutralize toxic lipid peroxides, the depletion of GSH directly weakens the cell's most critical line of defense against ferroptosis (105)

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